Registered interventional trials fail to cover patient-prioritised treatments in Post-COVID condition (PCC)

08.09.2026 · Zusammenfassung auf Deutsch

We need to produce JSON with "zusammenfassung" and "relevanz". Must be German, <=1200 characters. Summarize the study: registered interventional trials fail to cover patient-prioritised treatments in Post-COVID condition (PCC). Provide what was examined: 854 registry records deduplicated to 714 unique interventional trials, categorized interventions, endpoints. Results: only 51 of 714 trials (7.1%) tested any of the 29 patient-guide treatments; 20 active. Post-exertional malaise captured in 57 trials but primary endpoint only in eight. Ten guide treatments had no registered trial. German registry contributed none. Evidence concentrated on antivirals, immunoglobulins, hyperbaric oxygen. Only three of eight trials with PEM as primary tested intervention targeting proposed driver; none addressed microvascular or bioenergetic mechanisms. Conclusion: emphasis on symptomatic treatment, need for mechanism-based disease-modifying trials. We need to translate terms: Post-COVID condition (PCC) = Langzeitfolgen nach COVID-19. Post-exertional malaise (PEM) = Verschlimmerung nach Belastung, Kernsymptom bei ME/CFS. Mechanism-oriented endpoints = Ziel ist, Krankheitsmechanismus zu verstehen. Sym