Medikamentoese Behandlung bei ME/CFS - Stand der Forschung

Ausgewertet: 136 Studien mit 203 Einzelbefunden · Stand 05.10.2026

Diese Übersicht fasst den Stand der Forschung zusammen. Sie ist keine ärztliche Beratung und keine Behandlungsempfehlung. Ob eine Behandlung im Einzelfall sinnvoll ist, kann nur eine Ärztin oder ein Arzt beurteilen. Die Texte wurden automatisch erstellt und können Fehler enthalten - maßgeblich sind die verlinkten Originalstudien.

Verschreibungspflichtige Medikamente

In Erforschung, mit ersten positiven Hinweisen

HPV-Impfung (Impfprogramm) (1 Studie(n), davon 1 am Menschen)
- Effects of human papillomavirus (HPV) vaccination programmes on community rates of HPV-related disease and harms from vaccination.
Ivabradin (1 Studie(n), davon 1 am Menschen)
- Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS).
Betablocker (2 Studie(n), davon 2 am Menschen)
- Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS).
- The Clinical Relevance of Mast Cell Activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Midodrin (1 Studie(n), davon 1 am Menschen)
- Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS).
Pyridostigmin (3 Studie(n), davon 3 am Menschen)
- Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS).
- Pyridostigmine improves hand grip strength in patients with myalgic encephalomyelitis/chronic fatigue syndrome.
Rapamycin (niedrig dosiert) (2 Studie(n), davon 2 am Menschen)
- Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.
- Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study.
Compound Ciwujia Granulat (Eleutherococcus/Taigawurzel-Präparat) (1 Studie(n), davon 1 am Menschen)
- [Compound Ciwujia Granules for chronic fatigue syndrome with syndrome of deficiency of both heart and spleen: a multicenter, randomized, double-blind, double-dummy, positive drug-controlled trial].
Guipi Granulat (TCM-Vergleichspräparat) (1 Studie(n), davon 1 am Menschen)
- [Compound Ciwujia Granules for chronic fatigue syndrome with syndrome of deficiency of both heart and spleen: a multicenter, randomized, double-blind, double-dummy, positive drug-controlled trial].
Solriamfetol (1 Studie(n), davon 1 am Menschen)
- Solriamfetol improves daily fatigue symptoms in adults with myalgic encephalomyelitis/chronic fatigue syndrome after 8 weeks of treatment.

Zu wenig Daten für eine Aussage

Medikamentöse Behandlung (unspezifiziert) (1 Studie(n), davon 1 am Menschen)
- Impacts of Post-Covid Condition (PCC) in Sweden: a cross-sectional observational survey study.
C1-Esterase-Inhibitor-Infusion (1 Studie(n), davon 1 am Menschen)
- Does C1 esterase inhibitor play a role in post COVID-19 neurological symptoms? A randomized, double-blind, placebo-controlled, crossover, proof-of-concept study
Ketamin (1 Studie(n), davon 1 am Menschen)
- A preliminary proof-of-concept trial on the effects of ketamine on fatigue: a randomized crossover trial.
Midazolam (1 Studie(n), davon 1 am Menschen)
- A preliminary proof-of-concept trial on the effects of ketamine on fatigue: a randomized crossover trial.
Medikamente gegen Kreislaufprobleme (2 Studie(n), davon 2 am Menschen)
- Management of long COVID-19 in children and adolescents: from diagnosis to therapeutically approaches
Low-Dose Naltrexone (LDN) (7 Studie(n), davon 6 am Menschen)
Metformin (3 Studie(n), davon 2 am Menschen)
Immunmodulierende Medikamente (1 Studie(n), davon 1 am Menschen)
- Therapeutic plasma exchange and immunomodulatory strategies in post-infectious syndromes: A review of immune dysregulation in PTLDS, long COVID, ME/CFS, and PANS/PANDAS.
Gegen fehlgeleitete Antikörper gerichtete Behandlungen (Immuntherapie) (1 Studie(n), davon 1 am Menschen)
- Expert perspectives on Myalgic encephalomyelitis/chronic fatigue syndrome - Insights from the 3
Medikamentöse Maßnahmen bei POTS (1 Studie(n), davon 1 am Menschen)
- [Post-COVID: An inventory focusing on the key complaints PEM and POTS].
Antithrombotische Medikation (Blutplättchen‑hemmende Medikamente) (1 Studie(n), davon 1 am Menschen)
- Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients
Antivirale Therapie gegen Epstein‑Barr‑Virus (EBV) (1 Studie(n), davon 1 am Menschen)
- Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients

Bisher nur im Labor oder im Tierversuch untersucht

Saxagliptin (3 Studie(n), davon 0 am Menschen)
Impfstoff‑Kandidat gegen verschiedene Coronavirus‑Varianten (1 Studie(n), davon 0 am Menschen)
- Editorial: Therapeutic targets and strategies for long COVID and post-viral syndrome
Vildagliptin (2 Studie(n), davon 0 am Menschen)
- Comment on "SMPDL3B as a novel biomarker and therapeutic target in myalgic encephalomyelitis" critical considerations on biomarker validation and Supraphysiological drug concentrations.
- SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis
Hemmung des Enzyms PLA2G4A (1 Studie(n), davon 0 am Menschen)
- Hyperbaric oxygen alleviates CFS-like cognitive impairment via PLA2G4A-linked glycerophospholipid metabolism.
Pioglitazon (1 Studie(n), davon 0 am Menschen)
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) gene expression signatures for the identification of compounds targeting metabolism
Tideglusib (1 Studie(n), davon 0 am Menschen)
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) gene expression signatures for the identification of compounds targeting metabolism
MHY1485 (1 Studie(n), davon 0 am Menschen)
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) gene expression signatures for the identification of compounds targeting metabolism
Rosiglitazon (1 Studie(n), davon 0 am Menschen)
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) gene expression signatures for the identification of compounds targeting metabolism
22 computergestützt identifizierte Medikamente (u.a. Leflunomid, Melatonin, Midodrin) (1 Studie(n), davon 0 am Menschen)
- iPSC-Derived Myogenic Progenitor Cells from People with ME/CFS Reveal Altered Genes and Pathways with Drug Repurposing Potential
Progesteron (MR-Blocker) (1 Studie(n), davon 0 am Menschen)
- Comparison of transcriptional activation by corticosteroids of human MR (Ile-180) and haplotype (Val-180)
Kynurenin-Administration (Injektion) (1 Studie(n), davon 0 am Menschen)
- Potential Region-Specific Neuroprotective Effects of Kynurenine Administration in Healthy Rodents Using High-Resolution Mass Spectrometry.
Methylophiopogonanone B (MOB) (1 Studie(n), davon 0 am Menschen)
- Integrated GNPS Molecular Networking and Network Pharmacology Uncover Methylophiopogonanone B as a Novel Anti-Inflammatory Agent From Polygonatum cyrtonema Hua Targeting the SRC-PI3K-Akt Pathway

Ohne nachgewiesene Wirkung oder mit Hinweis auf Schaden

Nirmatrelvir/Ritonavir (1 Studie(n), davon 1 am Menschen)
- Clinical practice guideline for long COVID prevention and treatment.
Kortison-Präparate (1 Studie(n), davon 1 am Menschen)
- Clinical practice guideline for long COVID prevention and treatment.
Ondansetron (1 Studie(n), davon 1 am Menschen)
- The effect of ondansetron, a 5-HT3 receptor antagonist, in chronic fatigue syndrome: a randomized controlled trial
Anakinra (1 Studie(n), davon 1 am Menschen)
- Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment
Betamethason/Prednisolon (stark wirksame Glukokortikoide) (1 Studie(n), davon 1 am Menschen)
- Corticosteroids with low glucocorticoid activity as a potential therapeutic strategy for post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome in patients with bipolar affective disorder: A case report.
Avacopan (1 Studie(n), davon 1 am Menschen)
- Antineutrophil Cytoplasmic Antibody (ANCA) Vasculitis, Fatigue, and Treatment With Avacopan: A Case Series
Nirmatrelvir‑Ritonavir (Paxlovid) (1 Studie(n), davon 1 am Menschen)
- Nirmatrelvir-ritonavir targeting viral persistence in post-COVID-19 condition (long COVID) in the USA (RECOVER-VITAL): a randomised, double-blind, placebo-controlled, phase 2 trial.

Nahrungsergänzung, Phytotherapie und frei verkäufliche Mittel

In Erforschung, mit ersten positiven Hinweisen

Probiotika (5 Studie(n), davon 5 am Menschen)
Synbiotika/Probiotika zur Beeinflussung des Darmmikrobioms (1 Studie(n), davon 1 am Menschen)
- Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based systematic review.
Pflanzenstoffe (pflanzliche Wirkstoffe zur Beeinflussung des Mikrobioms) (1 Studie(n), davon 1 am Menschen)
- Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based systematic review.
YC-1101 (enzymatisch aufbereiteter Hirschgeweih-Extrakt) (1 Studie(n), davon 1 am Menschen)
- Efficacy and Safety of Enzyme-Derived Deer Velvet Extract Supplementation on Adults with Chronic Fatigue: a Randomized, Placebo-Controlled, Double-Blind Trial.
Vitamin-D-Präparate (alleinige Gabe) (1 Studie(n), davon 1 am Menschen)
- Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
Coenzym Q10 (Nahrungsergänzung) (6 Studie(n), davon 5 am Menschen)

Zu wenig Daten für eine Aussage

Japanische traditionelle (Kampo) Medizin (1 Studie(n), davon 1 am Menschen)
- Factors involved in the improvement of prolonged symptoms in patients with COVID-19 treated with Japanese traditional (Kampo) medicine: A single-center, prospective, observational study
Curcumin (kombiniert mit Phosphatidylcholin) (2 Studie(n), davon 2 am Menschen)
- Dietary Phytonutrients in Fibromyalgia: Integrating Mechanisms, Biomarkers, and Clinical Evidence-A Narrative Review
- The Effect of Curcumin in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Disparate Responses in Different Disease Severities
wasserstoffreiches Wasser (molekularer Wasserstoff, H₂) (1 Studie(n), davon 1 am Menschen)
- Molecular hydrogen as a treatment for ME/CFS: a mini-review of clinical evidence and mechanistic rationale.
Traditionelle chinesische Medizin (1 Studie(n), davon 1 am Menschen)
- Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): diagnosis and management.
SCFA-Ergänzungen (kurzkettige Fettsäuren) (1 Studie(n), davon 1 am Menschen)
- The microbiota-gut-brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention.
L-Carnitin (2 Studie(n), davon 2 am Menschen)
- Micronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
- Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review
Xiaoyao San (traditionelle chinesische Kräutermischung) (1 Studie(n), davon 1 am Menschen)
- Commentary: Efficacy and safety of Xiaoyao San in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis.
B-Vitamine (1 Studie(n), davon 1 am Menschen)
- Micronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
Magnesium (1 Studie(n), davon 1 am Menschen)
- Micronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
Kreatin (1 Studie(n), davon 1 am Menschen)
- Micronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
Heilerde (1 Studie(n), davon 1 am Menschen)
- Intestinal permeability correlated with chronic fatigue in a patient with long COVID-A case report and overview of the literature
Wasserstoffwasser (1 Studie(n), davon 1 am Menschen)

Bisher nur im Labor oder im Tierversuch untersucht

Kombination Saxagliptin und Myo-Inositol (1 Studie(n), davon 0 am Menschen)
- Authors' Response to "Comment on 'SMPDL3B as a novel biomarker and therapeutic target in myalgic encephalomyelitis'".
Ginseng-Stengel-Blatt-Saponine (GSLS) (1 Studie(n), davon 0 am Menschen)
- UHPLC-Q-Exactive Orbitrap MS-based brain-gut metabolomics implicates multi-pathway modulation by Ginseng stem-leaf saponins in chronic fatigue syndrome mice.
Lycium ruthenicum Polysaccharid (WIPButyrate) (1 Studie(n), davon 0 am Menschen)
- WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
Shengyang Sanhuo Decoction (1 Studie(n), davon 0 am Menschen)
- Shengyang Sanhuo decoction and its disassembled prescriptions improve chronic fatigue syndrome in mice: Insights from lipid metabolism and autophagy.
Bestandteile von Shengyang Sanhuo Decoction (1 Studie(n), davon 0 am Menschen)
- Shengyang Sanhuo decoction and its disassembled prescriptions improve chronic fatigue syndrome in mice: Insights from lipid metabolism and autophagy.
Sijunzi-Dezoktion (traditionelle chinesische Kräutermedizin) (1 Studie(n), davon 0 am Menschen)
- Study on Sijunzi decoction regulating intestinal microbiota structure and metabolic profile for improving chronic fatigue syndrome.
Coenzym Q10 und Alpha-Liponsäure (1 Studie(n), davon 0 am Menschen)
- Targeting Bioenergetic, Redox and Prostaglandin Pathways in Long COVID-Associated Post-Exertional Malaise and Brain Fog: A Nutraceutical Translational Hypothesis
Selen, Sulforaphan und Resveratrol (1 Studie(n), davon 0 am Menschen)
- Targeting Bioenergetic, Redox and Prostaglandin Pathways in Long COVID-Associated Post-Exertional Malaise and Brain Fog: A Nutraceutical Translational Hypothesis
Weihrauch (Boswellia), Luteolin und Fischöl (EPA) (1 Studie(n), davon 0 am Menschen)
- Targeting Bioenergetic, Redox and Prostaglandin Pathways in Long COVID-Associated Post-Exertional Malaise and Brain Fog: A Nutraceutical Translational Hypothesis
Gefriergetrocknete Kamelmilch (1 Studie(n), davon 0 am Menschen)
- Camel Milk Alleviates Chronic Fatigue Syndrome-like Symptoms in Mice by Modulating the Small Intestinal Microbiota and Inflammation.
Diosgenin (1 Studie(n), davon 0 am Menschen)
- Immunomodulatory and locomotor regulations via Diosgenin treatment in lipopolysaccharide-induced chronic fatigue syndrome (CFS)/ depressive despair symptom: an in vivo assessment.
Kamelmilch (1 Studie(n), davon 0 am Menschen)
- The Potential Role of Camel Milk in Alleviating Chronic Fatigue Syndrome in Mice: A Network Pharmacology and In Vivo Validation Study.

Ohne nachgewiesene Wirkung oder mit Hinweis auf Schaden

Vitamin E (1 Studie(n), davon 1 am Menschen)
- Vitamin and mineral status in chronic fatigue syndrome and fibromyalgia syndrome: A systematic review and meta-analysis
Vitamine und Mineralstoffe (allgemein) (1 Studie(n), davon 1 am Menschen)
- Vitamin and mineral status in chronic fatigue syndrome and fibromyalgia syndrome: A systematic review and meta-analysis

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